Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway

Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localised tension via a coordinated mechanochemical...

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Bibliographic Details
Published in:Nat Mater
Main Authors: Chronopoulos, Antonios, Thorpe, Stephen D., Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair J., Mykuliak, Vasyl V., Róg, Tomasz, Lee, David A., Hytönen, Vesa P., del Río Hernández, Armando E.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260055/
https://ncbi.nlm.nih.gov/pubmed/31907416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41563-019-0567-1
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