GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA

The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff fibrotic matrix, and the epithelial–mesenchymal transition (EMT) promote invasion...

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Pubblicato in:Cancers (Basel)
Autori principali: Rice, Alistair, Cortes, Ernesto, Lachowski, Dariusz, Oertle, Philipp, Matellan, Carlos, Thorpe, Stephen D., Ghose, Ritobrata, Wang, Haiyun, Lee, David A., Plodinec, Marija, del Río Hernández, Armando E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073197/
https://ncbi.nlm.nih.gov/pubmed/31991740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020289
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