Mechanotransduction in talin through the interaction of the R8 domain with DLC1

The mechanical unfolding of proteins is a cellular mechanism for force transduction with potentially broad implications in cell fate. Despite this, the mechanism by which protein unfolding elicits differential downstream signalling pathways remains poorly understood. Here, we used protein engineerin...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Haining, Alexander William M., Rahikainen, Rolle, Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair, von Essen, Magdalena, Hytönen, Vesa P., del Río Hernández, Armando
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Short Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054372/
https://ncbi.nlm.nih.gov/pubmed/30028837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005599
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