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Mechanical unfolding reveals stable 3-helix intermediates in talin and α-catenin

Mechanical stability is a key feature in the regulation of structural scaffolding proteins and their functions. Despite the abundance of α-helical structures among the human proteome and their undisputed importance in health and disease, the fundamental principles of their behavior under mechanical...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Mykuliak, Vasyl V., Haining, Alexander William M., von Essen, Magdaléna, del Río Hernández, Armando, Hytönen, Vesa P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940241/
https://ncbi.nlm.nih.gov/pubmed/29698481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006126
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