B cell–intrinsic TLR9 expression is protective in murine lupus

Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To begin to address this question, we created 2 alleles to manipulate TLR9 expression, allowing for ei...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Tilstra, Jeremy S., John, Shinu, Gordon, Rachael A., Leibler, Claire, Kashgarian, Michael, Bastacky, Sheldon, Nickerson, Kevin M., Shlomchik, Mark J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260024/
https://ncbi.nlm.nih.gov/pubmed/32191633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132328
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