B cell–intrinsic TLR9 expression is protective in murine lupus

Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To begin to address this question, we created 2 alleles to manipulate TLR9 expression, allowing for ei...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Tilstra, Jeremy S., John, Shinu, Gordon, Rachael A., Leibler, Claire, Kashgarian, Michael, Bastacky, Sheldon, Nickerson, Kevin M., Shlomchik, Mark J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260024/
https://ncbi.nlm.nih.gov/pubmed/32191633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132328
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