B cell–intrinsic TLR9 expression is protective in murine lupus

Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To begin to address this question, we created 2 alleles to manipulate TLR9 expression, allowing for ei...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Tilstra, Jeremy S., John, Shinu, Gordon, Rachael A., Leibler, Claire, Kashgarian, Michael, Bastacky, Sheldon, Nickerson, Kevin M., Shlomchik, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260024/
https://ncbi.nlm.nih.gov/pubmed/32191633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132328
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