Taxane resistance in prostate cancer is mediated by decreased drug-target engagement

Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be established, and there is no way of predicting who will respond to therapy. This study examined prostate cancer (PCa) xenografts and patient samples to identify in vivo mechanisms of taxane action and resista...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Gjyrezi, Ada, Xie, Fang, Voznesensky, Olga, Khanna, Prateek, Calagua, Carla, Bai, Yang, Kung, Justin, Wu, Jim, Corey, Eva, Montgomery, Bruce, Mace, Sandrine, Gianolio, Diego A., Bubley, Glenn J., Balk, Steven P., Giannakakou, Paraskevi, Bhatt, Rupal S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2020
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259995/
https://ncbi.nlm.nih.gov/pubmed/32478682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132184
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