Taxane resistance in prostate cancer is mediated by decreased drug-target engagement

Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be established, and there is no way of predicting who will respond to therapy. This study examined prostate cancer (PCa) xenografts and patient samples to identify in vivo mechanisms of taxane action and resista...

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發表在:J Clin Invest
Main Authors: Gjyrezi, Ada, Xie, Fang, Voznesensky, Olga, Khanna, Prateek, Calagua, Carla, Bai, Yang, Kung, Justin, Wu, Jim, Corey, Eva, Montgomery, Bruce, Mace, Sandrine, Gianolio, Diego A., Bubley, Glenn J., Balk, Steven P., Giannakakou, Paraskevi, Bhatt, Rupal S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259995/
https://ncbi.nlm.nih.gov/pubmed/32478682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132184
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