Taxane resistance in prostate cancer is mediated by decreased drug-target engagement

Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be established, and there is no way of predicting who will respond to therapy. This study examined prostate cancer (PCa) xenografts and patient samples to identify in vivo mechanisms of taxane action and resista...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Gjyrezi, Ada, Xie, Fang, Voznesensky, Olga, Khanna, Prateek, Calagua, Carla, Bai, Yang, Kung, Justin, Wu, Jim, Corey, Eva, Montgomery, Bruce, Mace, Sandrine, Gianolio, Diego A., Bubley, Glenn J., Balk, Steven P., Giannakakou, Paraskevi, Bhatt, Rupal S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259995/
https://ncbi.nlm.nih.gov/pubmed/32478682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132184
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