Quantitative analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRXL301, a nanoparticle of docetaxel

Aim: We reviewed the radiographic response of three patients with metastatic castration-resistant prostate cancer treated with CRXL301, a docetaxel nanoparticle. For these three patients, we isolated and analyzed circulating tumor cells (CTCs) to explore microtubule (MT) drug-target engagement (MT-D...

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Detalhes bibliográficos
Publicado no:Cancer Drug Resist
Main Authors: Mukhtar, Eiman, Worroll, Daniel, Galletti, Giuseppe, Schuster, Shelly, Piha-Paul, Sarina A., Giannakakou, Paraskevi
Formato: Artigo
Idioma:Inglês
Publicado em: OAE Publishing Inc. 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556717/
https://ncbi.nlm.nih.gov/pubmed/33062959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20517/cdr.2019.116
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