Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer

Prostate cancer progression requires active androgen receptor (AR) signaling which occurs following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes improves survival in patients with castrate resistant prostate cancer (CRPC). Taxanes induce microtubule stabilization,...

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Main Authors: Darshan, Medha S., Loftus, Matthew S., Thadani-Mulero, Maria, Levy, Ben P., Escuin, Daniel, Zhou, Xi Kathy, Gjyrezi, Ada, Chanel-Vos, Chantal, Shen, Ruoqian, Tagawa, Scott T., Bander, Neil H., Nanus, David M., Giannakakou, Paraskevi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354631/
https://ncbi.nlm.nih.gov/pubmed/21799031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1417
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