Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer

Prostate cancer progression requires active androgen receptor (AR) signaling which occurs following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes improves survival in patients with castrate resistant prostate cancer (CRPC). Taxanes induce microtubule stabilization,...

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Hauptverfasser: Darshan, Medha S., Loftus, Matthew S., Thadani-Mulero, Maria, Levy, Ben P., Escuin, Daniel, Zhou, Xi Kathy, Gjyrezi, Ada, Chanel-Vos, Chantal, Shen, Ruoqian, Tagawa, Scott T., Bander, Neil H., Nanus, David M., Giannakakou, Paraskevi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354631/
https://ncbi.nlm.nih.gov/pubmed/21799031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1417
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