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A Loss of Function of the Mitochondrial Branched-Chain Aminotransferase (BCATm) Leads to Increased Glycolytic and Oxidative Metabolism in Activated CD4+ T Cells

OBJECTIVES: T cells use the amino acid leucine to respond to their increased biosynthetic demands during activation. However, once inside T cells, leucine is subjected to degradation, which is initiated by the mitochondrial branched-chain aminotransferase (BCATm) that catalyzes the reversible transa...

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Publicat a:Curr Dev Nutr
Autors principals: Ananieva, Elitsa, Toress, Ashley, Powell, Jonathan, Hutson, Susan, Boyer, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259131/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa068_002
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