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Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4(+) T Cells

Here we show that expression of the cytosolic branched chain aminotransferase (BCATc) is triggered by the T cell receptor (TCR) of CD4(+) T cells. Induction of BCATc correlates with increased Leu transamination, whereas T cells from the BCATc(−/−) mouse exhibit lower Leu transamination and higher in...

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Autores principales: Ananieva, Elitsa A., Patel, Chirag H., Drake, Charles H., Powell, Jonathan D., Hutson, Susan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081922/
https://ncbi.nlm.nih.gov/pubmed/24847056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554113
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