A Loss of Function of the Mitochondrial Branched-Chain Aminotransferase (BCATm) Leads to Increased Glycolytic and Oxidative Metabolism in Activated CD4+ T Cells

OBJECTIVES: T cells use the amino acid leucine to respond to their increased biosynthetic demands during activation. However, once inside T cells, leucine is subjected to degradation, which is initiated by the mitochondrial branched-chain aminotransferase (BCATm) that catalyzes the reversible transa...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Curr Dev Nutr
Hlavní autoři: Ananieva, Elitsa, Toress, Ashley, Powell, Jonathan, Hutson, Susan, Boyer, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Nutritional Immunology and Inflammation/Immunometabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259131/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa068_002
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky