Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Anticoagulant protein S (PS) in platelets (PS(plt)) resembles plasma PS and is released on platelet activation, but its role in thrombosis has not been elucidated. Here we report that inactivation of PS(plt) expression using the Platelet factor 4 (Pf4)-Cre transgene (Pros1(lox/lox)Pf4-Cre(+)) in mic...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Calzavarini, Sara, Prince-Eladnani, Raja, Saller, François, Bologna, Luca, Burnier, Laurent, Brisset, Anne C., Quarroz, Claudia, Reina Caro, Maria Desiré, Ermolayev, Vladimir, Matsumura, Yasuhiro, Fernández, José A., Hackeng, Tilman M., Griffin, John H., Angelillo-Scherrer, Anne
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256357/
https://ncbi.nlm.nih.gov/pubmed/32276277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003630
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