Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Anticoagulant protein S (PS) in platelets (PS(plt)) resembles plasma PS and is released on platelet activation, but its role in thrombosis has not been elucidated. Here we report that inactivation of PS(plt) expression using the Platelet factor 4 (Pf4)-Cre transgene (Pros1(lox/lox)Pf4-Cre(+)) in mic...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Calzavarini, Sara, Prince-Eladnani, Raja, Saller, François, Bologna, Luca, Burnier, Laurent, Brisset, Anne C., Quarroz, Claudia, Reina Caro, Maria Desiré, Ermolayev, Vladimir, Matsumura, Yasuhiro, Fernández, José A., Hackeng, Tilman M., Griffin, John H., Angelillo-Scherrer, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256357/
https://ncbi.nlm.nih.gov/pubmed/32276277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003630
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