Generation and phenotypic analysis of protein S–deficient mice

Protein S (PS) is an important natural anticoagulant with potentially multiple biologic functions. To investigate further the role of PS in vivo, we generated Pros(+/−) heterozygous mice. In the null (−) allele, the Pros exons 3 to 7 have been excised through conditional gene targeting. Pros(+/−) mi...

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Detalhes bibliográficos
Main Authors: Saller, François, Brisset, Anne C., Tchaikovski, Svetlana N., Azevedo, Monica, Chrast, Roman, Fernández, José A., Schapira, Marc, Hackeng, Tilman M., Griffin, John H., Angelillo-Scherrer, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745849/
https://ncbi.nlm.nih.gov/pubmed/19567881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-209031
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