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Maintaining extraembryonic expression allows generation of mice with severe tissue factor pathway inhibitor deficiency
Tissue factor pathway inhibitor (TFPI) is a serine protease with multiple anticoagulant activities. The Kunitz1 (K1) domain of TFPI binds the active site of factor VIIa and is required for inhibition of tissue factor (TF)/factor VIIa catalytic activity. Mice lacking TFPI K1 domain die in utero. TFPI...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6373739/ https://ncbi.nlm.nih.gov/pubmed/30755437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018018853 |
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