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Extraembryonic expression of EPCR is essential for embryonic viability
The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary f...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895308/ https://ncbi.nlm.nih.gov/pubmed/15956290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0406 |
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