Extraembryonic expression of EPCR is essential for embryonic viability

The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary f...

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Bibliografske podrobnosti
Main Authors: Li, Weihong, Zheng, Xunzhen, Gu, Jian-Ming, Ferrell, Gary L., Brady, Mingming, Esmon, Naomi L., Esmon, Charles T.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Hematology 2005
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895308/
https://ncbi.nlm.nih.gov/pubmed/15956290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0406
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