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Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

Although the involvement of plasminogen activator inhibitor-1 (PAI-1) in fibrotic diseases is well documented, its role in cardiac fibrosis remains controversial. The goal of this study was to determine the effect of a PAI-1 deficiency (PAI-1(−/−)) on the spontaneous development of cardiac fibrosis....

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Detalhes bibliográficos
Main Authors: Xu, Zhi, Castellino, Francis J., Ploplis, Victoria A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837335/
https://ncbi.nlm.nih.gov/pubmed/20009036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-244962
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