Epigenetic preconditioning with decitabine sensitizes glioblastoma to temozolomide via induction of MLH1

INTRODUCTION: To improve the standard treatment paradigm for glioblastoma (GBM), efforts have been made to explore the efficacy of epigenetic agents as chemosensitizers. Recent data suggest possible synergy between decitabine (DAC), a DNA hypomethylating agent, and temozolomide (TMZ) in GBM, but the...

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Udgivet i:J Neurooncol
Main Authors: Gallitto, Matthew, Cheng He, Rossana, Inocencio, Julio F., Wang, Huaien, Zhang, Yizhou, Deikus, Gintaras, Wasserman, Isaac, Strahl, Maya, Smith, Melissa, Sebra, Robert, Yong, Raymund L.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
Fag:
Laboratory Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256087/
https://ncbi.nlm.nih.gov/pubmed/32193690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03461-4
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