Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma

Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GBM), it remains unclear which molecule is associated with GBM recurrence. We isolated three TMZ-resistant human GBM cell lines and examined the expression of O(6)-methylguanine-DNA meth...

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Detalhes bibliográficos
Main Authors: Shinsato, Yoshinari, Furukawa, Tatsuhiko, Yunoue, Shunji, Yonezawa, Hajime, Minami, Kentarou, Nishizawa, Yukihiko, Ikeda, Ryuji, Kawahara, Kohichi, Yamamoto, Masatatsu, Hirano, Hirofumi, Tokimura, Hiroshi, Arita, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926825/
https://ncbi.nlm.nih.gov/pubmed/24259277
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