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GENE-20. USE OF DECITABINE TO ALTER PATTERNS OF TREATMENT-INDUCED MUTAGENESIS IN GLIOBLASTOMA
The standard chemoradiation strategy used to treat GBM triggers cell death by inducing overwhelming numbers of DNA double-strand breaks (DSBs). Cancer cells escaping apoptosis activate error-prone DNA damage response mechanisms that have the potential to produce new mutations in critical driver gene...
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| Publié dans: | Neuro Oncol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692087/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.394 |
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