GENE-20. USE OF DECITABINE TO ALTER PATTERNS OF TREATMENT-INDUCED MUTAGENESIS IN GLIOBLASTOMA

The standard chemoradiation strategy used to treat GBM triggers cell death by inducing overwhelming numbers of DNA double-strand breaks (DSBs). Cancer cells escaping apoptosis activate error-prone DNA damage response mechanisms that have the potential to produce new mutations in critical driver gene...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Gallitto, Matthew, Pain, Margaret, Wang, Huaien, Deikus, Gintaras, Sebra, Robert, Yong, Raymund
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692087/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.394
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