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Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma
BACKGROUND: Gliosarcoma is a rare variant of glioblastoma (GBM) that exhibits frequent mutations in TP53 and can develop in a secondary fashion after chemoradiation of a primary GBM. Whether temozolomide (TMZ)-induced mutagenesis of the TP53 DNA-binding domain (DBD) can drive the pathogenesis of gli...
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| Publicado no: | Oncotarget |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788663/ https://ncbi.nlm.nih.gov/pubmed/29416795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23517 |
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