Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

TP53 mutations have been linked to reduced survival in patients with oral cavity squamous cell carcinoma (OSCC). However, the impact of different types of TP53 mutations remains unclear. Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutatio...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Lapke, Nina, Lu, Yen-Jung, Liao, Chun-Ta, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Ng, Shu-Hang, Chen, Shu-Jen, Yen, Tzu-Chen
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190089/
https://ncbi.nlm.nih.gov/pubmed/27283772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9925
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