Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

TP53 mutations have been linked to reduced survival in patients with oral cavity squamous cell carcinoma (OSCC). However, the impact of different types of TP53 mutations remains unclear. Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutatio...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lapke, Nina, Lu, Yen-Jung, Liao, Chun-Ta, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Ng, Shu-Hang, Chen, Shu-Jen, Yen, Tzu-Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190089/
https://ncbi.nlm.nih.gov/pubmed/27283772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9925
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