Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

TP53 mutations have been linked to reduced survival in patients with oral cavity squamous cell carcinoma (OSCC). However, the impact of different types of TP53 mutations remains unclear. Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutatio...

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Vydáno v:Oncotarget
Hlavní autoři: Lapke, Nina, Lu, Yen-Jung, Liao, Chun-Ta, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Ng, Shu-Hang, Chen, Shu-Jen, Yen, Tzu-Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190089/
https://ncbi.nlm.nih.gov/pubmed/27283772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9925
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