Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an increased risk of pancreatic cancer. Branched...

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Udgivet i:Signal Transduct Target Ther
Main Authors: Lei, Ming-Zhu, Li, Xu-Xu, Zhang, Ye, Li, Jin-Tao, Zhang, Fan, Wang, Yi-Ping, Yin, Miao, Qu, Jia, Lei, Qun-Ying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256045/
https://ncbi.nlm.nih.gov/pubmed/32467562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0168-0
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