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Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
The mammalian target of rapamycin complex 1 (mTORC1) plays an important role in the development and progression of multiple cancers. Its activity is regulated by both growth factor and nutrient signals, and the branched-chain amino acid (BCAA) leucine plays an important and unique role in this proce...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6512911/ https://ncbi.nlm.nih.gov/pubmed/31131306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1585171 |
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