Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone

Dysregulation of hormone metabolism is implicated in human breast cancer. 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) catalyzes the conversion of estradiol (E2) to estrone (E1), and is associated with the pathogenesis and development of various cancers. Here we show that E1 upregulates HSD17B4...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Zhang, Ye, Xu, Ying-Ying, Yao, Chuan-Bo, Li, Jin-Tao, Zhao, Xiang-Ning, Yang, Hong-Bin, Zhang, Min, Yin, Miao, Chen, Jing, Lei, Qun-Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361611/
https://ncbi.nlm.nih.gov/pubmed/28296597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1268302
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