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The Contribution of 17beta-Hydroxysteroid Dehydrogenase Type 1 to the Estradiol-Estrone Ratio in Estrogen-Sensitive Breast Cancer Cells

Estrone and estradiol are both estrogens with estrone being the less potent form and estradiol being the most potent estrogen. The binding of the latter to cellular regulatory elements stimulates the proliferation of breast cancer cells. A high ratio of estradiol/estrone is related to increased cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Chen-Yan, Chen, Jiong, Yin, Da-Chuan, Lin, Sheng-Xiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253791/
https://ncbi.nlm.nih.gov/pubmed/22253796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029835
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