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A mitochondrial journey through acetaminophen hepatotoxicity

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the United States and APAP-induced hepatotoxicity is initiated by formation of a reactive metabolite which depletes hepatic glutathione and forms protein adducts. Studies over the years have established the critical role of...

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Bibliografiska uppgifter
I publikationen:Food Chem Toxicol
Huvudupphovsmän: Ramachandran, Anup, Jaeschke, Hartmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254872/
https://ncbi.nlm.nih.gov/pubmed/32209353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2020.111282
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