Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy

Dose control of warfarin is a major complication in anticoagulation therapy and overdose is reversed by the vitamin K antidote. Improving the dosage management and antidotal efficacy requires mechanistic understanding. Here we find that effects of the major predictor of warfarin dosage, SNP −1639 G&...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Li, Shuang, Liu, Shixuan, Liu, Xiaoran Roger, Zhang, Mengru Mira, Li, Weikai
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252542/
https://ncbi.nlm.nih.gov/pubmed/32433747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001750
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