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Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy
Dose control of warfarin is a major complication in anticoagulation therapy and overdose is reversed by the vitamin K antidote. Improving the dosage management and antidotal efficacy requires mechanistic understanding. Here we find that effects of the major predictor of warfarin dosage, SNP −1639 G&...
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| Publié dans: | Blood Adv |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7252542/ https://ncbi.nlm.nih.gov/pubmed/32433747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001750 |
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