Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

The anticoagulant warfarin inhibits the vitamin K oxidoreductase (VKORC1), which generates vitamin K hydroquinone (KH(2)) required for the carboxylation and consequent activation of vitamin K–dependent (VKD) proteins. VKORC1 produces KH(2) in 2 reactions: reduction of vitamin K epoxide (KO) to quino...

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Bibliographic Details
Published in:Blood
Main Authors: Rishavy, Mark A., Hallgren, Kevin W., Wilson, Lee, Singh, Savita, Runge, Kurt W., Berkner, Kathleen L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014353/
https://ncbi.nlm.nih.gov/pubmed/29592891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-804666
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