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Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase
The anticoagulant warfarin inhibits the vitamin K oxidoreductase (VKORC1), which generates vitamin K hydroquinone (KH(2)) required for the carboxylation and consequent activation of vitamin K–dependent (VKD) proteins. VKORC1 produces KH(2) in 2 reactions: reduction of vitamin K epoxide (KO) to quino...
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| 發表在: | Blood |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6014353/ https://ncbi.nlm.nih.gov/pubmed/29592891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-804666 |
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