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Engineering Dynamic Surface Peptide Networks on Butyrylcholinesterase(G117H) for Enhanced Organophosphosphorus Anticholinesterase Catalysis
The single residue mutation of butyrylcholinesterase (BChE(G117H)) hydrolyzes a number of organophosphosphorus (OP) anticholinesterases. While other active site/proximal mutations have been investigated, none are sufficiently active to be prophylactically useful. In a fundamentally different, comput...
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| Veröffentlicht in: | Chem Res Toxicol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7251593/ https://ncbi.nlm.nih.gov/pubmed/31411024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00146 |
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