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Evolutionarily Conserved Linkage between Enzyme Fold, Flexibility, and Catalysis

Proteins are intrinsically flexible molecules. The role of internal motions in a protein's designated function is widely debated. The role of protein structure in enzyme catalysis is well established, and conservation of structural features provides vital clues to their role in function. Recent...

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Detalhes bibliográficos
Main Authors: Ramanathan, Arvind, Agarwal, Pratul K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210774/
https://ncbi.nlm.nih.gov/pubmed/22087074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001193
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