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On the relationship between folding and chemical landscapes in enzyme catalysis

Elucidating the relationship between the folding landscape of enzymes and their catalytic power has been one of the challenges of modern enzymology. The present work explores this issue by using a simplified folding model to generate the free-energy landscape of an enzyme and then to evaluate the ac...

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Detalhes bibliográficos
Main Authors: Roca, Maite, Messer, Benjamin, Hilvert, Donald, Warshel, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544547/
https://ncbi.nlm.nih.gov/pubmed/18779576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803405105
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