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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
The proposal that enzymatic catalysis is due to conformational fluctuations has been previously promoted by means of indirect considerations. However, recent works have focused on cases where the relevant motions have components toward distinct conformational regions, whose population could be manip...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3161549/ https://ncbi.nlm.nih.gov/pubmed/21831831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111252108 |
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