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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
The proposal that enzymatic catalysis is due to conformational fluctuations has been previously promoted by means of indirect considerations. However, recent works have focused on cases where the relevant motions have components toward distinct conformational regions, whose population could be manip...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3161549/ https://ncbi.nlm.nih.gov/pubmed/21831831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111252108 |
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