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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

The proposal that enzymatic catalysis is due to conformational fluctuations has been previously promoted by means of indirect considerations. However, recent works have focused on cases where the relevant motions have components toward distinct conformational regions, whose population could be manip...

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書誌詳細
主要な著者: Adamczyk, Andrew J., Cao, Jie, Kamerlin, Shina C. L., Warshel, Arieh
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161549/
https://ncbi.nlm.nih.gov/pubmed/21831831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111252108
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