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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

The proposal that enzymatic catalysis is due to conformational fluctuations has been previously promoted by means of indirect considerations. However, recent works have focused on cases where the relevant motions have components toward distinct conformational regions, whose population could be manip...

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Hlavní autoři: Adamczyk, Andrew J., Cao, Jie, Kamerlin, Shina C. L., Warshel, Arieh
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161549/
https://ncbi.nlm.nih.gov/pubmed/21831831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111252108
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