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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

The proposal that enzymatic catalysis is due to conformational fluctuations has been previously promoted by means of indirect considerations. However, recent works have focused on cases where the relevant motions have components toward distinct conformational regions, whose population could be manip...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Adamczyk, Andrew J., Cao, Jie, Kamerlin, Shina C. L., Warshel, Arieh
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161549/
https://ncbi.nlm.nih.gov/pubmed/21831831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111252108
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