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Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase

One of the fundamental challenges in biotechnology and in biochemistry is the ability to design effective enzymes. Doing so would be a convincing manifestation of a full understanding of the origin of enzyme catalysis. Despite an impressive progress, most of the advances on this front have been made...

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Detalhes bibliográficos
Main Authors: Frushicheva, Maria P., Cao, Jie, Chu, Zhen T., Warshel, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947920/
https://ncbi.nlm.nih.gov/pubmed/20829491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010381107
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