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A redox-mediated Kemp eliminase
The acid/base-catalysed Kemp elimination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform of enzymes with non-natural reactions, providing new mechanistic insights in protein science. Here we describe an alternative concept based on redox catalysis by P450-...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5379065/ https://ncbi.nlm.nih.gov/pubmed/28348375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14876 |
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