Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Minimalist enzymes designed to catalyze model reactions provide useful starting points for creating catalysts for practically important chemical transformations. We have shown that Kemp eliminases of the AlleyCat family facilitate conversion of leflunomide (an immunosupressor pro-drug) to its active...

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Detalhes bibliográficos
Publicado no:ChemCatChem
Main Authors: Caselle, Elizabeth A., Yoon, Jennifer H., Bhattacharya, Sagar, Rempillo, Joel J.L., Lengyel, Zsófia, D’Souza, Areetha, Moroz, Yurii S., Tolbert, Patricia L., Volkov, Alexander N., Forconi, Marcello, Castañeda, Carlos A., Makhlynets, Olga V., Korendovych, Ivan V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884320/
https://ncbi.nlm.nih.gov/pubmed/31788134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201801994
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