Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Minimalist enzymes designed to catalyze model reactions provide useful starting points for creating catalysts for practically important chemical transformations. We have shown that Kemp eliminases of the AlleyCat family facilitate conversion of leflunomide (an immunosupressor pro-drug) to its active...

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Publicat a:ChemCatChem
Autors principals: Caselle, Elizabeth A., Yoon, Jennifer H., Bhattacharya, Sagar, Rempillo, Joel J.L., Lengyel, Zsófia, D’Souza, Areetha, Moroz, Yurii S., Tolbert, Patricia L., Volkov, Alexander N., Forconi, Marcello, Castañeda, Carlos A., Makhlynets, Olga V., Korendovych, Ivan V.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884320/
https://ncbi.nlm.nih.gov/pubmed/31788134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201801994
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