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Challenges and Advances in Validating Enzyme Design Proposals: The Case of the Kemp Eliminase Catalysis
One of the fundamental challenges in biotechnology and biochemistry is the ability to design effective enzymes. Despite recent progress, most of the advances on this front have been made by placing the reacting fragments in the proper places, rather than by optimizing the preorganization of the envi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086991/ https://ncbi.nlm.nih.gov/pubmed/21443179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200063a |
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