Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis

Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises a set of signaling mechanisms that initiate a gene expression program to res...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Bugallo, Ricardo, Marlin, Elías, Baltanás, Ana, Toledo, Estefanía, Ferrero, Roberto, Vinueza-Gavilanes, Rodrigo, Larrea, Laura, Arrasate, Montserrat, Aragón, Tomás
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250913/
https://ncbi.nlm.nih.gov/pubmed/32457286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2601-2
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