Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis. The mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, highlighting disturbances in motoneuron proteostasis. Endoplasmic reticul...

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Udgivet i:Front Mol Neurosci
Main Authors: Medinas, Danilo B., González, Jose V., Falcon, Paulina, Hetz, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496948/
https://ncbi.nlm.nih.gov/pubmed/28725179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00216
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