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The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Although the etiology remains unclear, disturbances in calcium homoeostasis and protein folding are essential features of neurodegeneration in this disorder. Here, w...

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Bibliographische Detailangaben
Hauptverfasser: Tadic, Vedrana, Prell, Tino, Lautenschlaeger, Janin, Grosskreutz, Julian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039088/
https://ncbi.nlm.nih.gov/pubmed/24910594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00147
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