Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-PBMCs is related to disease aggressiveness. W...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Prell, Tino, Stubendorff, Beatrice, Le, Thanh Tu, Gaur, Nayana, Tadić, Vedrana, Rödiger, Annekathrin, Witte, Otto W., Grosskreutz, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355670/
https://ncbi.nlm.nih.gov/pubmed/30740050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00005
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