Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis

Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises a set of signaling mechanisms that initiate a gene expression program to res...

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Publicado en:Cell Death Dis
Main Authors: Bugallo, Ricardo, Marlin, Elías, Baltanás, Ana, Toledo, Estefanía, Ferrero, Roberto, Vinueza-Gavilanes, Rodrigo, Larrea, Laura, Arrasate, Montserrat, Aragón, Tomás
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250913/
https://ncbi.nlm.nih.gov/pubmed/32457286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2601-2
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